CEBPB Antikörper (pThr235)

Produktnummer ABIN6256518

Produktdetails anti-CEBPB Antikörper

Target: CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))

Bindungsspezifität: pThr235

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEBPB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Phospho-CEBP Beta (Thr235/Thr188) Antibody detects endogenous levels of CEBP Beta only when phosphorylated at Threonine 235.

Homologie: Pig,Bovine,Rabbit,Dog

Aufreinigung: The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

Immunogen: A synthesized peptide derived from human C/EBP- beta around the phosphorylation site of Thr235.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CEBPB

Target: CEBPB (CCAAT/enhancer Binding Protein (C/EBP), beta (CEBPB))

Andere Bezeichnung: CEBPB (CEBPB Produkte)

Synonyme: C/EBPbeta antikoerper, c/ebp-beta antikoerper, crp2 antikoerper, il6dbp antikoerper, lap antikoerper, nf-il6 antikoerper, tcf5 antikoerper, xC/EBPbeta antikoerper, cebpbb antikoerper, cb380 antikoerper, c/ebpb antikoerper, fe11e05 antikoerper, wu:fe11e05 antikoerper, CEBPB antikoerper, LOC100136165 antikoerper, C/EBP-beta antikoerper, CRP2 antikoerper, IL6DBP antikoerper, LAP antikoerper, NF-IL6 antikoerper, TCF5 antikoerper, IL-6DBP antikoerper, LIP antikoerper, NF-M antikoerper, Nfil6 antikoerper, Il6dbp antikoerper, CCAAT/enhancer binding protein beta antikoerper, CCAAT/enhancer binding protein beta L homeolog antikoerper, CCAAT/enhancer binding protein (C/EBP), beta antikoerper, CCAAT/enhancer-binding protein beta antikoerper, cebpb antikoerper, cebpb.L antikoerper, CEBPB antikoerper, LOC100136165 antikoerper, Cebpb antikoerper

Hintergrund:

Description: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1, represses expression of DSPP during odontoblast differentiation (By similarity).

Gene: CEBPB

Molekulargewicht: 36kDa

Gen-ID: 1051

UniProt: P17676

Pathways: Interferon-gamma Pathway, Autophagie, Brown Fat Cell Differentiation