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MAPK13 Antikörper (C-Term)

MAPK13 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256863
  • Target Alle MAPK13 Antikörper anzeigen
    MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 71
    • 25
    • 23
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 56
    • 12
    • 3
    Kaninchen
    Klonalität
    • 58
    • 13
    Polyklonal
    Konjugat
    • 31
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAPK13 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 31
    • 13
    • 13
    • 10
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    MAPK13 Antibody detects endogenous levels of total MAPK13.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MAPK13, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product MAPK13 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))
    Andere Bezeichnung
    MAPK13 (MAPK13 Produkte)
    Synonyme
    F24B9.3 antikoerper, F24B9_3 antikoerper, MAPK 13 antikoerper, MAPK-13 antikoerper, PRKM13 antikoerper, SAPK4 antikoerper, p38delta antikoerper, Serk4 antikoerper, Prkm13 antikoerper, sapk4 antikoerper, prkm13 antikoerper, Protein kinase superfamily protein antikoerper, mitogen-activated protein kinase 13 antikoerper, mitogen activated protein kinase 13 antikoerper, ATMPK13 antikoerper, MAPK13 antikoerper, Mapk13 antikoerper, mapk13 antikoerper
    Hintergrund

    Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

    Gene: MAPK13

    Molekulargewicht
    42 kDa
    Gen-ID
    5603
    UniProt
    O15264
    Pathways
    MAPK Signalweg, Neurotrophin Signalübertragung, Hepatitis C, BCR Signaling, S100 Proteine
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