AATF Antikörper (N-Term)
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- Target Alle AATF Antikörper anzeigen
- AATF (Apoptosis Antagonizing Transcription Factor (AATF))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser AATF Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- AATF Antibody detects endogenous levels of total AATF.
- Homologie
- Pig,Bovine,Horse,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human AATF, corresponding to a region within N-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product AATF Primärantikörper
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- Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- AATF (Apoptosis Antagonizing Transcription Factor (AATF))
- Andere Bezeichnung
- AATF (AATF Produkte)
- Synonyme
- AATF antikoerper, ded antikoerper, che1 antikoerper, che-1 antikoerper, cb109 antikoerper, sb:cb109 antikoerper, wu:fc13d05 antikoerper, zgc:162071 antikoerper, CHE-1 antikoerper, CHE1 antikoerper, DED antikoerper, 4933415H02Rik antikoerper, 5830465M17Rik antikoerper, Che-1 antikoerper, Trb antikoerper, Ded antikoerper, apoptosis antagonizing transcription factor antikoerper, Apoptosis antagonizing transcription factor antikoerper, apoptosis antagonizing transcription factor S homeolog antikoerper, AATF antikoerper, aatf antikoerper, BFR2 antikoerper, NAEGRDRAFT_56916 antikoerper, Aatf antikoerper, aatf.S antikoerper
- Hintergrund
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Description: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Gene: AATF
- Molekulargewicht
- 63 kDa
- Gen-ID
- 26574
- UniProt
- Q9NY61
- Pathways
- Neurotrophin Signalübertragung, SARS-CoV-2 Protein Interaktom
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