AKAP13 Antikörper (Internal Region)

Produktnummer ABIN6256897

Produktdetails anti-AKAP13 Antikörper

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser AKAP13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: AKAP13 Antibody detects endogenous levels of total AKAP13.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human AKAP13, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu AKAP13

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Andere Bezeichnung: AKAP13 (AKAP13 Produkte)

Synonyme: AKAP13 antikoerper, brx antikoerper, lbc antikoerper, ha-3 antikoerper, ht31 antikoerper, c-lbc antikoerper, MGC81410 antikoerper, akap-lbc antikoerper, arhgef13 antikoerper, proto-lb antikoerper, proto-lbc antikoerper, AKAP-13 antikoerper, AKAP-Lbc antikoerper, ARHGEF13 antikoerper, BRX antikoerper, HA-3 antikoerper, Ht31 antikoerper, LBC antikoerper, PRKA13 antikoerper, PROTO-LB antikoerper, PROTO-LBC antikoerper, p47 antikoerper, 1700026G02Rik antikoerper, 5730522G15Rik antikoerper, 5830460E08Rik antikoerper, A-kinase anchoring protein 13 antikoerper, A-kinase anchoring protein 13 S homeolog antikoerper, A kinase (PRKA) anchor protein 13 antikoerper, AKAP13 antikoerper, akap13.S antikoerper, akap13 antikoerper, Akap13 antikoerper

Hintergrund:

Description: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:25186459, PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:23716597, PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117, PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).

Gene: AKAP13

Molekulargewicht: 307 kDa

Gen-ID: 11214

UniProt: Q12802

Pathways: Neurotrophin Signalübertragung