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BRSK1 Antikörper (Internal Region)

BRSK1 Reaktivität: Human, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6256963
  • Target Alle BRSK1 Antikörper anzeigen
    BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
    Bindungsspezifität
    • 15
    • 10
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 51
    • 31
    • 20
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 73
    Kaninchen
    Klonalität
    • 72
    • 1
    Polyklonal
    Konjugat
    • 21
    • 8
    • 8
    • 7
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BRSK1 Antikörper ist unkonjugiert
    Applikation
    • 47
    • 37
    • 14
    • 13
    • 13
    • 10
    • 7
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    BRSK1 Antibody detects endogenous levels of total BRSK1.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human BRSK1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product BRSK1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    BRSK1 (BR Serine/threonine Kinase 1 (BRSK1))
    Andere Bezeichnung
    BRSK1 (BRSK1 Produkte)
    Synonyme
    BRSK1 antikoerper, hSAD1 antikoerper, Gm1100 antikoerper, SAD-B antikoerper, SADB antikoerper, RGD1563268 antikoerper, Sad-b antikoerper, BR serine/threonine kinase 1 antikoerper, BRSK1 antikoerper, Brsk1 antikoerper
    Hintergrund

    Description: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C.

    Gene: BRSK1

    Molekulargewicht
    87 kDa
    Gen-ID
    84446
    UniProt
    Q8TDC3
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