CCBP2 Antikörper (C-Term)

Produktnummer ABIN6257026

Produktdetails anti-CCBP2 Antikörper

Target: CCBP2 (Chemokine Binding Protein 2 (CCBP2))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: CCBP2 Antibody detects endogenous levels of total CCBP2.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CCBP2, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu CCBP2

Target: CCBP2 (Chemokine Binding Protein 2 (CCBP2))

Andere Bezeichnung: ACKR2 (CCBP2 Produkte)

Synonyme: CCBP2 antikoerper, CCR10 antikoerper, CCR9 antikoerper, CMKBR9 antikoerper, D6 antikoerper, hD6 antikoerper, Ccbp2 antikoerper, LOC733624 antikoerper, A130091K22Rik antikoerper, Cmkbr10 antikoerper, GPR-9-6 antikoerper, AI464239 antikoerper, Cmkbr9 antikoerper, atypical chemokine receptor 2 antikoerper, atypical chemokine receptor 2-like antikoerper, chemokine receptor D6 antikoerper, chemokine (C-C motif) receptor 9 antikoerper, C-C motif chemokine receptor 9 antikoerper, ACKR2 antikoerper, Ackr2 antikoerper, LOC100219492 antikoerper, LOC733624 antikoerper, Ccr9 antikoerper, CCR9 antikoerper

Hintergrund:

Description: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.

Gene: ACKR2

Molekulargewicht: 34 kDa

Gen-ID: 1238

UniProt: O00590