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CDK5RAP3 Antikörper

CDK5RAP3 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257054
  • Target Alle CDK5RAP3 Antikörper anzeigen
    CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))
    Reaktivität
    • 49
    • 15
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 47
    • 2
    Kaninchen
    Klonalität
    • 47
    • 2
    Polyklonal
    Konjugat
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CDK5RAP3 Antikörper ist unkonjugiert
    Applikation
    • 33
    • 14
    • 13
    • 13
    • 7
    • 7
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    CDK5RAP3 Antibody detects endogenous levels of total CDK5RAP3
    Kreuzreaktivität
    Human, Maus, Ratte (Rattus)
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide
    Isotyp
    IgG
    Top Product
    Discover our top product CDK5RAP3 Primärantikörper
  • Applikationshinweise
    WB 1:500~1:1000, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    CDK5RAP3 (CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))
    Andere Bezeichnung
    CDK5RAP3 (CDK5RAP3 Produkte)
    Synonyme
    cdkrap3 antikoerper, fb33h04 antikoerper, fc09c05 antikoerper, id:ibd2920 antikoerper, wu:fb33h04 antikoerper, wu:fc09c05 antikoerper, zgc:86863 antikoerper, CDK5RAP3 antikoerper, cdk5rap3 antikoerper, MGC82350 antikoerper, C53 antikoerper, HSF-27 antikoerper, IC53 antikoerper, LZAP antikoerper, MST016 antikoerper, OK/SW-cl.114 antikoerper, PP1553 antikoerper, 1810007E24Rik antikoerper, BC002318 antikoerper, C81486 antikoerper, CDK5 regulatory subunit associated protein 3 antikoerper, CDK5 regulatory subunit associated protein 3 L homeolog antikoerper, cdk5rap3 antikoerper, CDK5RAP3 antikoerper, cdk5rap3.L antikoerper, Cdk5rap3 antikoerper
    Hintergrund

    Description: Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629).

    Gene: CDK5RAP3

    Molekulargewicht
    60 kDa
    Gen-ID
    80279
    UniProt
    Q96JB5
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