Casein Kinase 1 delta Antikörper (Internal Region)

Produktnummer ABIN6257097

Produktdetails anti-Casein Kinase 1 delta Antikörper

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Casein Kinase 1 delta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: Casein Kinase 1 delta Antibody detects endogenous levels of total Casein Kinase 1 delta.

Homologie: Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human Casein Kinase 1 delta, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu Casein Kinase 1 delta

Target: Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))

Andere Bezeichnung: CSNK1D (CSNK1D Produkte)

Synonyme: ASPS antikoerper, CKIdelta antikoerper, FASPS2 antikoerper, HCKID antikoerper, 1200006A05Rik antikoerper, AA409348 antikoerper, D930010H05Rik antikoerper, CKI-delta antikoerper, CKId antikoerper, csnk1d antikoerper, wu:fb69b03 antikoerper, wu:fj97a05 antikoerper, zgc:77627 antikoerper, CSNK1D antikoerper, ckIdelta antikoerper, Csnk1d antikoerper, csnk1dl antikoerper, wu:fb50c04 antikoerper, zgc:63971 antikoerper, casein kinase 1 delta antikoerper, casein kinase 1, delta antikoerper, casein kinase 1, delta b antikoerper, casein kinase 1 delta S homeolog antikoerper, casein kinase 1, delta a antikoerper, CSNK1D antikoerper, Csnk1d antikoerper, csnk1d antikoerper, csnk1db antikoerper, Bm1_37175 antikoerper, csnk1d.S antikoerper, csnk1da antikoerper

Hintergrund:

Description: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.

Gene: CSNK1D

Molekulargewicht: 47 kDa

Gen-ID: 1453

UniProt: P48730

Pathways: Hedgehog Signalweg, M Phase