Cyclin T2 Antikörper (Internal Region)

Produktnummer ABIN6257122

Produktdetails anti-Cyclin T2 Antikörper

Target: Cyclin T2 (CCNT2)

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cyclin T2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: CCNT2 Antibody detects endogenous levels of total CCNT2.

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human CCNT2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu Cyclin T2

Target: Cyclin T2 (CCNT2)

Andere Bezeichnung: CCNT2 (CCNT2 Produkte)

Synonyme: fb16c03 antikoerper, wu:fb16c03 antikoerper, wu:fj68b10 antikoerper, zgc:55690 antikoerper, ccnt2 antikoerper, cycT antikoerper, wu:fi17h07 antikoerper, zgc:55357 antikoerper, MGC81210 antikoerper, CCNT2 antikoerper, CYCT2 antikoerper, 2900041I18Rik antikoerper, C81304 antikoerper, CycT2 antikoerper, CycT2b antikoerper, cyclin T2 antikoerper, cyclin T2b antikoerper, cyclin T2a antikoerper, cyclin T2 S homeolog antikoerper, CCNT2 antikoerper, ccnt2b antikoerper, ccnt2a antikoerper, ccnt2.S antikoerper, ccnt2 antikoerper, Ccnt2 antikoerper

Hintergrund:

Description: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation, P-TEFB complex interacts with MYOD1, this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes, this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity).

Gene: CCNT2

Molekulargewicht: 81kDa

Gen-ID: 905

UniProt: O60583