EIF3K Antikörper (N-Term)

Produktnummer ABIN6257176

Produktdetails anti-EIF3K Antikörper

Target: EIF3K (Eukaryotic Translation Initiation Factor 3 Subunit K (EIF3K))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EIF3K Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: EIF3K Antibody detects endogenous levels of total EIF3K.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human EIF3K, corresponding to a region within N-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu EIF3K

Target: EIF3K (Eukaryotic Translation Initiation Factor 3 Subunit K (EIF3K))

Andere Bezeichnung: EIF3K (EIF3K Produkte)

Synonyme: eif3s12 antikoerper, EIF3S12 antikoerper, ACYPI000023 antikoerper, eIF3k antikoerper, EIF3-p28 antikoerper, HSPC029 antikoerper, M9 antikoerper, MSTP001 antikoerper, PLAC-24 antikoerper, PLAC24 antikoerper, PRO1474 antikoerper, PTD001 antikoerper, 1200009C21Rik antikoerper, Eif3s12 antikoerper, zgc:110726 antikoerper, eukaryotic translation initiation factor 3 subunit K L homeolog antikoerper, eukaryotic translation initiation factor 3 subunit K antikoerper, eukaryotic translation initiation factor 3, subunit K antikoerper, eukaryotic translation initiation factor 3 subunit k antikoerper, Eukaryotic translation initiation factor 3 subunit K antikoerper, eif3k.L antikoerper, EIF3K antikoerper, eif3k antikoerper, ANI_1_1610144 antikoerper, AOR_1_2266174 antikoerper, Tsp_00068 antikoerper, Tsp_13184 antikoerper, Eif3k antikoerper, LOC733122 antikoerper, eif-3.K antikoerper

Hintergrund:

Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene: EIF3K

Molekulargewicht: 30 kDa

Gen-ID: 27335

UniProt: Q9UBQ5

Pathways: Ribonucleoprotein Complex Subunit Organization