PKN1 Antikörper (Internal Region)

Produktnummer ABIN6257420

Produktdetails anti-PKN1 Antikörper

Target: PKN1 (Protein Kinase N1 (PKN1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PKN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PKN1 Antibody detects endogenous levels of total PKN1.

Homologie: Pig,Bovine,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PKN1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PKN1

Target: PKN1 (Protein Kinase N1 (PKN1))

Andere Bezeichnung: PKN1 (PKN1 Produkte)

Synonyme: DBK antikoerper, PAK-1 antikoerper, PAK1 antikoerper, PKN antikoerper, PKN-ALPHA antikoerper, PRK1 antikoerper, PRKCL1 antikoerper, F730027O18Rik antikoerper, Pkn antikoerper, Prkcl1 antikoerper, Stk3 antikoerper, PKN1 antikoerper, 3-2 antikoerper, CG2049 antikoerper, CG2055 antikoerper, CT6637 antikoerper, CT6660 antikoerper, DPKN antikoerper, Dmel\\CG2049 antikoerper, Dpkn antikoerper, PRK2 antikoerper, Pk45C antikoerper, Pk?3 antikoerper, dPKN antikoerper, l(2)06736 antikoerper, l(2)45Ca antikoerper, v(2)rG232 antikoerper, protein kinase N1 antikoerper, protein kinase N1b antikoerper, Protein kinase N antikoerper, PKN1 antikoerper, Pkn1 antikoerper, pkn1b antikoerper, pkn1 antikoerper, Pkn antikoerper

Hintergrund:

Description: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.

Gene: PKN1

Molekulargewicht: 103 kDa

Gen-ID: 5585

UniProt: Q16512