PPP4R2 Antikörper (Internal Region)

Produktnummer ABIN6257426

Produktdetails anti-PPP4R2 Antikörper

Target: PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPP4R2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PPP4R2 Antibody detects endogenous levels of total PPP4R2.

Homologie: Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PPP4R2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PPP4R2

Target: PPP4R2 (Protein Phosphatase 4, Regulatory Subunit 2 (PPP4R2))

Andere Bezeichnung: PPP4R2 (PPP4R2 Produkte)

Synonyme: PP4R2 antikoerper, BE691708 antikoerper, C230060M08Rik antikoerper, ppp4r2 antikoerper, fe11b04 antikoerper, wu:fe11b04 antikoerper, ppp4r2-B antikoerper, wu:fa17h08 antikoerper, wu:fc23g05 antikoerper, protein phosphatase 4 regulatory subunit 2 antikoerper, protein phosphatase 4, regulatory subunit 2 antikoerper, protein phosphatase 4, regulatory subunit 2a antikoerper, protein phosphatase 4 regulatory subunit 2 S homeolog antikoerper, protein phosphatase 4 regulatory subunit 2 L homeolog antikoerper, protein phosphatase 4, regulatory subunit 2b antikoerper, PPP4R2 antikoerper, Ppp4r2 antikoerper, ppp4r2a antikoerper, ppp4r2.S antikoerper, ppp4r2 antikoerper, ppp4r2.L antikoerper, ppp4r2b antikoerper

Hintergrund:

Description: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.

Gene: PPP4R2

Molekulargewicht: 50 kDa

Gen-ID: 151987

UniProt: Q9NY27