RPS3 Antikörper (Internal Region)

Produktnummer ABIN6257472

Produktdetails anti-RPS3 Antikörper

Target: RPS3 (Ribosomal Protein S3 (RPS3))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RPS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: RPS3 Antibody detects endogenous levels of total RPS3.

Homologie: Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RPS3, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RPS3

Target: RPS3 (Ribosomal Protein S3 (RPS3))

Andere Bezeichnung: RPS3 (RPS3 Produkte)

Synonyme: S3 antikoerper, D7Ertd795e antikoerper, Rs_3 antikoerper, fb13d09 antikoerper, wu:fb13d09 antikoerper, zgc:56088 antikoerper, ribosomal protein S1a antikoerper, rps3 antikoerper, 6779 antikoerper, CG6779 antikoerper, DmRpS3 antikoerper, Dmel\\CG6779 antikoerper, M(3)124 antikoerper, M(3)95A antikoerper, M(3)B antikoerper, M(3)B2 antikoerper, M(3)Fla antikoerper, M(3)w antikoerper, M(3R)w antikoerper, M95A antikoerper, M[[w]] antikoerper, Mw antikoerper, RPS3 antikoerper, RS3 antikoerper, Rp S3 antikoerper, RpS antikoerper, Rps3 antikoerper, X72921 antikoerper, dS3 antikoerper, rpS3 antikoerper, rpls1b antikoerper, rpls3-b antikoerper, ribosomal protein S3 antikoerper, 40S ribosomal protein S3 antikoerper, ribosomal protein S3 L homeolog antikoerper, Ribosomal protein S3 antikoerper, 30S ribosomal protein S3 antikoerper, ribosomal protein S3 S homeolog antikoerper, RPS3 antikoerper, Rps3 antikoerper, rps-3 antikoerper, rps3 antikoerper, rps3.L antikoerper, RpS3 antikoerper, rps3.S antikoerper

Hintergrund:

Description: Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).

Gene: RPS3

Molekulargewicht: 30 kDa

Gen-ID: 6188

UniProt: P23396

Pathways: Positive Regulation of Endopeptidase Activity