TAO Kinase 1 (TAOK1) (Internal Region) Antikörper

Produktnummer ABIN6257515

Produktdetails

Target: TAO Kinase 1 (TAOK1)

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: TAOK1 Antibody detects endogenous levels of total TAOK1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human TAOK1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Antigendetails

Target: TAO Kinase 1 (TAOK1)

Andere Bezeichnung: TAOK1 (TAOK1 Produkte)

Synonyme: TAOK1 antikoerper, LOC733788 antikoerper, KFC-B antikoerper, MAP3K16 antikoerper, MARKK antikoerper, PSK-2 antikoerper, PSK2 antikoerper, TAO1 antikoerper, hKFC-B antikoerper, hTAOK1 antikoerper, 2810468K05Rik antikoerper, AU020252 antikoerper, D130018F14Rik antikoerper, Map3k16 antikoerper, Markk antikoerper, Psk2 antikoerper, mKIAA1361 antikoerper, taok1-b antikoerper, microRNA 4523 antikoerper, TAO kinase 1 antikoerper, serine/threonine-protein kinase TAO1 antikoerper, TAO kinase 1 S homeolog antikoerper, MIR4523 antikoerper, TAOK1 antikoerper, taok1 antikoerper, LOC100399784 antikoerper, Taok1 antikoerper, taok1.S antikoerper

Hintergrund:

Description: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.

Gene: TAOK1

Molekulargewicht: 120 kDa

Gen-ID: 57551

UniProt: Q7L7X3