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USP37 Antikörper (Internal Region)

USP37 Reaktivität: Human, Ratte ELISA, WB, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257545
  • Target Alle USP37 Antikörper anzeigen
    USP37 (Ubiquitin Specific Peptidase 37 (USP37))
    Bindungsspezifität
    • 8
    • 8
    • 8
    • 7
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 36
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte
    Wirt
    • 36
    Kaninchen
    Klonalität
    • 36
    Polyklonal
    Konjugat
    • 20
    • 4
    • 4
    • 4
    • 2
    • 2
    Dieser USP37 Antikörper ist unkonjugiert
    Applikation
    • 24
    • 22
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    USP37 Antibody detects endogenous levels of total USP37.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human USP37, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product USP37 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    USP37 (Ubiquitin Specific Peptidase 37 (USP37))
    Andere Bezeichnung
    USP37 (USP37 Produkte)
    Synonyme
    4932415L06Rik antikoerper, C330008N13Rik antikoerper, wu:fi15b04 antikoerper, wu:fi38d03 antikoerper, zgc:152882 antikoerper, zgc:153999 antikoerper, ubiquitin specific peptidase 37 antikoerper, USP37 antikoerper, usp37 antikoerper, Usp37 antikoerper
    Hintergrund

    Description: Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872).

    Gene: USP37

    Molekulargewicht
    ?120 kDa
    Gen-ID
    57695
    UniProt
    Q86T82
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