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NCBP1 Antikörper (N-Term)

NCBP1 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257658
  • Target Alle NCBP1 Antikörper anzeigen
    NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
    Bindungsspezifität
    • 15
    • 14
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 47
    • 31
    • 13
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 58
    • 4
    Kaninchen
    Klonalität
    • 61
    • 2
    Polyklonal
    Konjugat
    • 25
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NCBP1 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 21
    • 13
    • 13
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    NCBP1 Antibody detects endogenous levels of total NCBP1.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human NCBP1, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product NCBP1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    NCBP1 (Nuclear Cap Binding Protein Subunit 1, 80kDa (NCBP1))
    Andere Bezeichnung
    NCBP1 (NCBP1 Produkte)
    Synonyme
    CBP80 antikoerper, CG7035 antikoerper, Dmel\\CG7035 antikoerper, EG:84H4.3 antikoerper, ncbp antikoerper, sto1 antikoerper, cbp80 antikoerper, AU014645 antikoerper, AW538051 antikoerper, NCBP antikoerper, Sto1 antikoerper, ncbp1 antikoerper, ABA HYPERSENSITIVE 1 antikoerper, ATCBP80 antikoerper, CAP-BINDING PROTEIN 80 antikoerper, ENS antikoerper, ENSALADA antikoerper, NUCLEAR CAP-BINDING PROTEIN CBP80 antikoerper, T10F5.8 antikoerper, T10F5_8 antikoerper, cap binding protein 80 antikoerper, nuclear cap binding protein subunit 1 antikoerper, nuclear cap binding protein subunit 1 S homeolog antikoerper, nuclear cap binding protein subunit 1, 80kDa antikoerper, nuclear cap binding protein subunit 1 L homeolog antikoerper, ARM repeat superfamily protein antikoerper, Nuclear cap-binding protein subunit 1-A antikoerper, Nuclear cap-binding protein subunit 1 antikoerper, Cbp80 antikoerper, ncbp1 antikoerper, ncbp1.S antikoerper, NCBP1 antikoerper, Ncbp1 antikoerper, ncbp1.L antikoerper, ABH1 antikoerper, nbp1a antikoerper, ncbp-1 antikoerper
    Hintergrund

    Description: Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure. Associates with NCBP3 to form an alternative cap-binding complex (CBC) which plays a key role in mRNA export and is particularly important in cellular stress situations such as virus infections. The conventional CBC with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus whereas the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role only in mRNA export. NCBP1/CBP80 is required for cell growth and viability (PubMed:26382858).

    Gene: NCBP1

    Molekulargewicht
    80 kDa
    Gen-ID
    4686
    UniProt
    Q09161
    Pathways
    Ribonucleoprotein Complex Subunit Organization, Photoperiodism, Methionine Biosynthetic Process
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