BUB1B Antikörper (C-Term)

Produktnummer ABIN6257686

Produktdetails anti-BUB1B Antikörper

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BUB1B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: BUB1B Antibody detects endogenous levels of total BUB1B.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BUB1B, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BUB1B

Target: BUB1B (Budding Uninhibited By Benzimidazoles 1 Homolog beta (Yeast) (BUB1B))

Andere Bezeichnung: BUB1B (BUB1B Produkte)

Synonyme: BUB1beta antikoerper, BUBR1 antikoerper, Bub1A antikoerper, MAD3L antikoerper, MVA1 antikoerper, SSK1 antikoerper, hBUBR1 antikoerper, AU045529 antikoerper, bub1b antikoerper, BUB1 antikoerper, BUB1-like antikoerper, BubR1 antikoerper, BubRI antikoerper, CG14030 antikoerper, CG14030/Bub1 antikoerper, Dmel\\CG14030 antikoerper, bub1 antikoerper, BUB1 mitotic checkpoint serine/threonine kinase B antikoerper, BUB1B, mitotic checkpoint serine/threonine kinase antikoerper, BUB1B, mitotic checkpoint serine/threonine kinase L homeolog antikoerper, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta antikoerper, Bub1 kinase antikoerper, BUB1B antikoerper, Bub1b antikoerper, bub1b.L antikoerper, bub1b antikoerper, Bub1 antikoerper

Hintergrund:

Description: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.

Gene: BUB1B

Molekulargewicht: 130 kDa

Gen-ID: 701

UniProt: O60566