TAO Kinase 2 Antikörper (Internal Region)
-
- Target Alle TAO Kinase 2 (TAOK2) Antikörper anzeigen
- TAO Kinase 2 (TAOK2)
-
Bindungsspezifität
- Internal Region
-
Reaktivität
- Human, Maus, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser TAO Kinase 2 Antikörper ist unkonjugiert
-
Applikation
- ELISA, Western Blotting (WB)
- Spezifität
- TAO2 Antibody detects endogenous levels of total TAO2.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TAO2, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product TAOK2 Primärantikörper
-
-
- Applikationshinweise
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
-
- Target
- TAO Kinase 2 (TAOK2)
- Andere Bezeichnung
- TAOK2 (TAOK2 Produkte)
- Synonyme
- MAP3K17 antikoerper, PSK antikoerper, PSK1 antikoerper, PSK1-BETA antikoerper, TAO1 antikoerper, TAO2 antikoerper, Tao2 antikoerper, 1110033K02Rik antikoerper, B230344N16 antikoerper, mKIAA0881 antikoerper, TAOK2 antikoerper, map3k17 antikoerper, psk antikoerper, psk1 antikoerper, tao1 antikoerper, tao2 antikoerper, TAO kinase 2 antikoerper, TAO kinase 2 L homeolog antikoerper, serine/threonine-protein kinase TAO2 antikoerper, TAOK2 antikoerper, Taok2 antikoerper, taok2.L antikoerper, taok2 antikoerper, LOC100085396 antikoerper
- Hintergrund
-
Description: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.
Gene: TAOK2
- Molekulargewicht
- 120 kDa
- Gen-ID
- 9344
- UniProt
- Q9UL54
- Pathways
- Cell-Cell Junction Organization
-