CCL20 Antikörper (Internal Region)
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- Target Alle CCL20 Antikörper anzeigen
- CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser CCL20 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- CCL20 Antibody detects endogenous levels of total CCL20.
- Homologie
- Pig,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CCL20, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product CCL20 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))
- Andere Bezeichnung
- CCL20 (CCL20 Produkte)
- Synonyme
- MIP-3ALPHA antikoerper, CCL20 antikoerper, si:dkey-150o13.1 antikoerper, CKb4 antikoerper, LARC antikoerper, MIP-3-alpha antikoerper, MIP-3a antikoerper, MIP3A antikoerper, SCYA20 antikoerper, ST38 antikoerper, MIP-3A antikoerper, MIP-3[a] antikoerper, Scya20 antikoerper, exodus-1 antikoerper, C-C motif chemokine ligand 20 antikoerper, chemokine (C-C motif) ligand 20b antikoerper, chemokine (C-C motif) ligand 20 antikoerper, CCL20 antikoerper, ccl20b antikoerper, Ccl20 antikoerper
- Hintergrund
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Description: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11352563, PubMed:11035086, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:9038201, PubMed:11352563). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255).
Gene: CCL20
- Molekulargewicht
- 11 kDa
- Gen-ID
- 6364
- UniProt
- P78556
- Pathways
- Phosphorylierungen bei SARS-CoV-2 Infektion
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