GNA13 Antikörper (N-Term)
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- Target Alle GNA13 Antikörper anzeigen
- GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser GNA13 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- GNA13 Antibody detects endogenous levels of total GNA13.
- Homologie
- Pig,Rabbit,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human GNA13, corresponding to a region within N-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product GNA13 Primärantikörper
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anti-Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13) (AA 1-377) antibody
GNA13 Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 6F6-B5 unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13) antibodyGNA13 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13) (AA 184-212) antibodyGNA13 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB36839 unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13) antibodyGNA13 Reaktivität: Human WB Wirt: Kaninchen Monoclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13) (N-Term) antibodyGNA13 Reaktivität: Human, Maus, Ratte, Kaninchen, Meerschweinchen, Schwein, Hamster, Affe, Huhn, Xenopus laevis WB Wirt: Kaninchen Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13) (N-Term) antibodyGNA13 Reaktivität: Human, Maus, Ratte, Kaninchen, Meerschweinchen, Zebrafisch (Danio rerio) WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))
- Andere Bezeichnung
- GNA13 (GNA13 Produkte)
- Hintergrund
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Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333).
Gene: GNA13
- Molekulargewicht
- 44 kDa
- Gen-ID
- 10672
- UniProt
- Q14344
- Pathways
- CXCR4-mediated Signaling Events
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