Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

POFUT1 Antikörper (C-Term)

POFUT1 Reaktivität: Human, Maus, Ratte WB, IHC, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6257766
  • Target Alle POFUT1 Antikörper anzeigen
    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))
    Bindungsspezifität
    • 13
    • 8
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 41
    • 10
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 40
    • 2
    Kaninchen
    Klonalität
    • 39
    • 2
    Polyklonal
    Konjugat
    • 27
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    Dieser POFUT1 Antikörper ist unkonjugiert
    Applikation
    • 35
    • 27
    • 22
    • 8
    • 8
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    POFUT1 Antibody detects endogenous levels of total POFUT1.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human POFUT1, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product POFUT1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    POFUT1 (Protein O-Fucosyltransferase 1 (POFUT1))
    Andere Bezeichnung
    POFUT1 (POFUT1 Produkte)
    Synonyme
    fut12 antikoerper, zgc:110472 antikoerper, o-fut antikoerper, o-fuc-t antikoerper, o-fuct-1 antikoerper, pofut1 antikoerper, DDD2 antikoerper, FUT12 antikoerper, O-FUT antikoerper, O-Fuc-T antikoerper, O-FucT-1 antikoerper, OFUCT1 antikoerper, mKIAA0180 antikoerper, Fut12 antikoerper, protein O-fucosyltransferase 1 antikoerper, POFUT1 antikoerper, pofut1 antikoerper, Pofut1 antikoerper
    Hintergrund

    Description: Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs).

    Gene: POFUT1

    Molekulargewicht
    44 kDa
    Gen-ID
    23509
    UniProt
    Q9H488
    Pathways
    Notch Signalweg, SARS-CoV-2 Protein Interaktom
Sie sind hier:
Kundenservice