BAF53A Antikörper (Internal Region)

Produktnummer ABIN6257926

Produktdetails anti-BAF53A Antikörper

Target: BAF53A (Actin-Like 6A (BAF53A))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BAF53A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ACTL6A Antibody detects endogenous levels of total ACTL6A.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ACTL6A, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu BAF53A

Target: BAF53A (Actin-Like 6A (BAF53A))

Andere Bezeichnung: ACTL6A (BAF53A Produkte)

Synonyme: ACTL6 antikoerper, ARPN-BETA antikoerper, Arp4 antikoerper, BAF53A antikoerper, INO80K antikoerper, 2810432C06Rik antikoerper, AI851094 antikoerper, ARP4 antikoerper, Actl6 antikoerper, Baf53a antikoerper, C79802 antikoerper, baf53a antikoerper, fb52e06 antikoerper, fl26e12 antikoerper, chunp6900 antikoerper, wu:fb52e06 antikoerper, wu:fl26e12 antikoerper, actl6 antikoerper, MGC75671 antikoerper, RGD1307747 antikoerper, ACTL6A antikoerper, ATARP4 antikoerper, F15H18.8 antikoerper, F15H18_8 antikoerper, actin-related protein 4 antikoerper, Actin-like protein 4 antikoerper, CaO19.5623 antikoerper, actin antikoerper, actl6a antikoerper, actl6a.L antikoerper, arp4 antikoerper, arpn-beta antikoerper, ino80k antikoerper, actin like 6A antikoerper, actin-like 6A antikoerper, actin-related protein 4 antikoerper, Arp4p antikoerper, actin like 6A S homeolog antikoerper, ACTL6A antikoerper, Actl6a antikoerper, actl6a antikoerper, ARP4 antikoerper, actl6a.S antikoerper

Hintergrund:

Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.

Gene: ACTL6A

Molekulargewicht: 47 kDa

Gen-ID: 86

UniProt: O96019

Pathways: Chromatin Binding, Photoperiodism