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Cullin 4B Antikörper (N-Term)

CUL4B Reaktivität: Human, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258095
  • Target Alle Cullin 4B (CUL4B) Antikörper anzeigen
    Cullin 4B (CUL4B)
    Bindungsspezifität
    • 7
    • 7
    • 7
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 60
    • 22
    • 20
    • 9
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 55
    • 5
    Kaninchen
    Klonalität
    • 57
    • 3
    Polyklonal
    Konjugat
    • 32
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser Cullin 4B Antikörper ist unkonjugiert
    Applikation
    • 40
    • 18
    • 9
    • 8
    • 7
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    CUL4B Antibody detects endogenous levels of total CUL4B.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CUL4B, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CUL4B Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    Cullin 4B (CUL4B)
    Andere Bezeichnung
    CUL4B (CUL4B Produkte)
    Synonyme
    MRXHF2 antikoerper, MRXS15 antikoerper, MRXSC antikoerper, SFM2 antikoerper, 2700050M05Rik antikoerper, AA409770 antikoerper, CUL-4B antikoerper, mKIAA0695 antikoerper, RGD1564494 antikoerper, im:7140950 antikoerper, im:7150765 antikoerper, MGC115611 antikoerper, Tb03.1J15.620 antikoerper, sfm2 antikoerper, mrxsc antikoerper, mrxhf2 antikoerper, cullin 4B antikoerper, cullin 4B S homeolog antikoerper, CUL4B antikoerper, Cul4b antikoerper, cul4b antikoerper, cul4b.S antikoerper, Tb927.3.1290 antikoerper
    Hintergrund

    Description: Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

    Gene: CUL4B

    Molekulargewicht
    99 kDa?
    Gen-ID
    8450
    UniProt
    Q13620
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