RAPGEF3 Antikörper (C-Term)

Produktnummer ABIN6258154

Produktdetails anti-RAPGEF3 Antikörper

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAPGEF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: RAPGEF3 Antibody detects endogenous levels of total RAPGEF3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RAPGEF3, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu RAPGEF3

Target: RAPGEF3 (Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))

Andere Bezeichnung: RAPGEF3 (RAPGEF3 Produkte)

Synonyme: RAPGEF3 antikoerper, epac antikoerper, si:dkey-27m20.2 antikoerper, CAMP-GEFI antikoerper, EPAC antikoerper, EPAC1 antikoerper, HSU79275 antikoerper, bcm910 antikoerper, 2310016P22Rik antikoerper, 9330170P05Rik antikoerper, Epac antikoerper, Epac1 antikoerper, Rap guanine nucleotide exchange factor 3 antikoerper, Rap guanine nucleotide exchange factor 3 S homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 3 antikoerper, RAPGEF3 antikoerper, rapgef3.S antikoerper, rapgef3 antikoerper, Rapgef3 antikoerper

Hintergrund:

Description: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.

Gene: RAPGEF3

Molekulargewicht: 110/100 kDa

Gen-ID: 10411

UniProt: O95398

Pathways: cAMP Metabolic Process