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MAPK12 Antikörper (Internal Region)

MAPK12 Reaktivität: Human, Maus, Ratte WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258157
  • Target Alle MAPK12 Antikörper anzeigen
    MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 60
    • 35
    • 11
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 48
    • 9
    • 3
    • 2
    Kaninchen
    Klonalität
    • 53
    • 9
    Polyklonal
    Konjugat
    • 39
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MAPK12 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 30
    • 23
    • 7
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    MAPK12 Antibody detects endogenous levels of total MAPK12.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human MAPK12, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product MAPK12 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
    Andere Bezeichnung
    MAPK12 (MAPK12 Produkte)
    Synonyme
    ATMPK12 antikoerper, MAPK12 antikoerper, T3F17.28 antikoerper, mitogen-activated protein kinase 12 antikoerper, MGC160082 antikoerper, si:dkey-14d8.5 antikoerper, erk6 antikoerper, etID309866.18 antikoerper, mapk12 antikoerper, sapk3 antikoerper, wu:fa05c12 antikoerper, zgc:101695 antikoerper, ERK3 antikoerper, ERK6 antikoerper, P38GAMMA antikoerper, PRKM12 antikoerper, SAPK-3 antikoerper, SAPK3 antikoerper, AW123708 antikoerper, Erk6 antikoerper, P38gamma antikoerper, Prkm12 antikoerper, Sapk3 antikoerper, mitogen-activated protein kinase 12 antikoerper, mitogen-activated protein kinase 12b antikoerper, mitogen-activated protein kinase 12a antikoerper, MPK12 antikoerper, MAPK12 antikoerper, mapk12b antikoerper, mapk12a antikoerper, Mapk12 antikoerper
    Hintergrund

    Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes, and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

    Gene: MAPK12

    Molekulargewicht
    ?42 kDa
    Gen-ID
    6300
    UniProt
    P53778
    Pathways
    MAPK Signalweg, Neurotrophin Signalübertragung, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteine
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