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USP28 Antikörper (N-Term)

USP28 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258349
  • Target Alle USP28 Antikörper anzeigen
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Bindungsspezifität
    • 15
    • 8
    • 7
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    N-Term
    Reaktivität
    • 40
    • 16
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 52
    • 2
    • 1
    Kaninchen
    Klonalität
    • 55
    Polyklonal
    Konjugat
    • 17
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP28 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 19
    • 13
    • 13
    • 13
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    USP28 Antibody detects endogenous levels of total USP28.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human USP28, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product USP28 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    USP28 (Ubiquitin Specific Peptidase 28 (USP28))
    Andere Bezeichnung
    USP28 (USP28 Produkte)
    Synonyme
    im:7138195 antikoerper, USP28 antikoerper, 9830148O20Rik antikoerper, AU022237 antikoerper, mKIAA1515 antikoerper, ubiquitin specific peptidase 28 antikoerper, USP28 antikoerper, usp28 antikoerper, Usp28 antikoerper
    Hintergrund

    Description: Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically interacting with isoform 1 of FBXW7 (FBW7alpha) in the nucleoplasm and counteracting ubiquitination of MYC by the SCF(FBW7) complex. In contrast, it does not interact with isoform 4 of FBXW7 (FBW7gamma) in the nucleolus, allowing MYC degradation and explaining the selective MYC degradation in the nucleolus. Deubiquitinates ZNF304, hence preventing ZNF304 degradation by the proteasome and leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) in a subset of colorectal cancers (CRC) cells (PubMed:24623306).

    Gene: USP28

    Molekulargewicht
    122 kDa
    Gen-ID
    57646
    UniProt
    Q96RU2
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