ATG16L1 Antikörper (C-Term)

Produktnummer ABIN6258588

Produktdetails anti-ATG16L1 Antikörper

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG16L1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ATG16L1 Antibody detects endogenous levels of total ATG16L1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ATG16L1, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ATG16L1

Target: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Andere Bezeichnung: ATG16L1 (ATG16L1 Produkte)

Synonyme: APG16L antikoerper, ATG16A antikoerper, ATG16L antikoerper, IBD10 antikoerper, WDR30 antikoerper, 1500009K01Rik antikoerper, Apg16l antikoerper, Atg16l antikoerper, Wdr30 antikoerper, atg16 antikoerper, atg16l antikoerper, fb57e05 antikoerper, wu:fb57e05 antikoerper, zgc:110147 antikoerper, autophagy related 16 like 1 antikoerper, autophagy related 16-like 1 (S. cerevisiae) antikoerper, autophagy related 16-like 1 antikoerper, autophagy related 16 like 1 S homeolog antikoerper, ATG16 autophagy related 16-like 1 (S. cerevisiae) antikoerper, ATG16L1 antikoerper, Atg16l1 antikoerper, atg16l1 antikoerper, atg16l1.S antikoerper

Hintergrund:

Description: Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane (PubMed:24553140, PubMed:23376921, PubMed:24954904, PubMed:27273576, PubMed:23392225). Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (PubMed:25645662). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response (PubMed:24238340). Instead, promotes with NOD2 an autophagy-dependent antibacterial pathway (PubMed:20637199). Plays a role in regulating morphology and function of Paneth cell (PubMed:18849966).

Gene: ATG16L1

Molekulargewicht: 69 kDa

Gen-ID: 55054

UniProt: Q676U5

Pathways: Autophagie