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ARID1B Antikörper (Internal Region)

ARID1B Reaktivität: Human, Ratte, Maus WB, IF, ELISA, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258593
  • Target Alle ARID1B Antikörper anzeigen
    ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))
    Bindungsspezifität
    • 15
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 31
    • 19
    • 13
    • 3
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 44
    • 2
    Kaninchen
    Klonalität
    • 44
    • 2
    Polyklonal
    Konjugat
    • 18
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ARID1B Antikörper ist unkonjugiert
    Applikation
    • 27
    • 13
    • 13
    • 11
    • 9
    • 9
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
    Spezifität
    BAF250B Antibody detects endogenous levels of total BAF250B.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human BAF250B, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product ARID1B Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))
    Andere Bezeichnung
    ARID1B (ARID1B Produkte)
    Synonyme
    fd07d11 antikoerper, si:dkey-60a16.3 antikoerper, wu:fd07d11 antikoerper, 8030481M12 antikoerper, 9330189K18Rik antikoerper, AI836955 antikoerper, Ardi1b antikoerper, B230217J03Rik antikoerper, mKIAA1235 antikoerper, 6A3-5 antikoerper, Smcf1 antikoerper, smcf-1 antikoerper, BAF250B antikoerper, BRIGHT antikoerper, DAN15 antikoerper, ELD/OSA1 antikoerper, MRD12 antikoerper, OSA2 antikoerper, P250R antikoerper, AT rich interactive domain 1B (SWI1-like) antikoerper, AT rich interactive domain 1B (SWI-like) antikoerper, AT-rich interaction domain 1B antikoerper, arid1b antikoerper, Arid1b antikoerper, ARID1B antikoerper
    Hintergrund

    Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).

    Gene: ARID1B

    Molekulargewicht
    170 kDa
    Gen-ID
    57492
    UniProt
    Q8NFD5
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