BCL11B Antikörper (Internal Region)

Produktnummer ABIN6258605

Produktdetails anti-BCL11B Antikörper

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Bindungsspezifität: Internal Region

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BCL11B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: BCL11B Antibody detects endogenous levels of total BCL11B.

Homologie: Pig,Bovine,Sheep,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human BCL11B, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu BCL11B

Target: BCL11B (B-Cell CLL/lymphoma 11B (Zinc Finger Protein) (BCL11B))

Andere Bezeichnung: BCL11B (BCL11B Produkte)

Synonyme: BCL11B antikoerper, 9130430L19Rik antikoerper, AI604821 antikoerper, B630002E05Rik antikoerper, BCL-11B antikoerper, Ctip2 antikoerper, Rit1 antikoerper, ATL1 antikoerper, ATL1-alpha antikoerper, ATL1-beta antikoerper, ATL1-delta antikoerper, ATL1-gamma antikoerper, CTIP-2 antikoerper, CTIP2 antikoerper, RIT1 antikoerper, ZNF856B antikoerper, hRIT1-alpha antikoerper, B-cell CLL/lymphoma 11B antikoerper, B cell leukemia/lymphoma 11B antikoerper, B-cell CLL/lymphoma 11B (zinc finger protein) antikoerper, BCL11B antikoerper, Bcl11b antikoerper

Hintergrund:

Description: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of the receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (PubMed:27959755). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4+ T-lymphocytes (PubMed:16809611). Tumor-suppressor that represses transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity). May also function in the P53-signaling pathway (By similarity).

Gene: BCL11B

Molekulargewicht: ?95 kDa

Gen-ID: 64919

UniProt: Q9C0K0