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CD177 Antikörper (Internal Region)

CD177 Reaktivität: Human, Ratte WB, IHC, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258621
  • Target Alle CD177 Antikörper anzeigen
    CD177 (CD177 Molecule (CD177))
    Bindungsspezifität
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 46
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    Human, Ratte
    Wirt
    • 29
    • 21
    Kaninchen
    Klonalität
    • 31
    • 19
    Polyklonal
    Konjugat
    • 24
    • 6
    • 5
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CD177 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 21
    • 12
    • 9
    • 9
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Spezifität
    CD177 Antibody detects endogenous levels of total CD177.
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CD177, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product CD177 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    CD177 (CD177 Molecule (CD177))
    Andere Bezeichnung
    CD177 (CD177 Produkte)
    Synonyme
    HNA-2a antikoerper, HNA2A antikoerper, NB1 antikoerper, NB1 GP antikoerper, PRV-1 antikoerper, PRV1 antikoerper, RGD1562941 antikoerper, CD177 antikoerper, MGC157159 antikoerper, 1190003K14Rik antikoerper, Pdp3 antikoerper, CD177 molecule antikoerper, CD177 antigen antikoerper, CD177 antikoerper, Cd177 antikoerper
    Hintergrund

    Description: In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676, PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface, may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).

    Gene: CD177

    Molekulargewicht
    ?46 kDa
    Gen-ID
    57126
    UniProt
    Q8N6Q3
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