NEIL3 Antikörper (C-Term)

Produktnummer ABIN6258631

Produktdetails anti-NEIL3 Antikörper

Target: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NEIL3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: NEIL3 Antibody detects endogenous levels of total NEIL3.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NEIL3, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NEIL3

Target: NEIL3 (Nei Endonuclease VIII-Like 3 (NEIL3))

Andere Bezeichnung: NEIL3 (NEIL3 Produkte)

Synonyme: RGD1310562 antikoerper, NEIL3 antikoerper, zgc:103553 antikoerper, neil3 antikoerper, MAC12.12 antikoerper, MAC12_12 antikoerper, FGP2 antikoerper, FPG2 antikoerper, NEI3 antikoerper, hFPG2 antikoerper, hNEI3 antikoerper, AI449477 antikoerper, BC034753 antikoerper, C85903 antikoerper, nei-like DNA glycosylase 3 antikoerper, nei like DNA glycosylase 3 antikoerper, GRF zinc finger / Zinc knuckle protein antikoerper, nei-like DNA glycosylase 3 L homeolog antikoerper, nei like 3 (E. coli) antikoerper, Neil3 antikoerper, NEIL3 antikoerper, neil3 antikoerper, AT5G13920 antikoerper, neil3.L antikoerper

Hintergrund:

Description: DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA, also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

Gene: NEIL3

Molekulargewicht: 68 kDa

Gen-ID: 55247

UniProt: Q8TAT5

Pathways: DNA Reparatur