TSEN2 Antikörper (Internal Region)
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- Target Alle TSEN2 Antikörper anzeigen
- TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TSEN2 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Spezifität
- TSEN2 Antibody detects endogenous levels of total TSEN2.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human TSEN2, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product TSEN2 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Haltbarkeit
- 12 months
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- Target
- TSEN2 (tRNA-splicing Endonuclease Subunit SEN2 (TSEN2))
- Andere Bezeichnung
- TSEN2 (TSEN2 Produkte)
- Synonyme
- AU067695 antikoerper, RGD1309946 antikoerper, PCH2B antikoerper, SEN2 antikoerper, SEN2L antikoerper, tRNA splicing endonuclease subunit 2 antikoerper, TSEN2 antikoerper, Tsen2 antikoerper
- Hintergrund
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Description: Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. Isoform 1 probably carries the active site for 5'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. Isoform 2 is responsible for processing a yet unknown RNA substrate. The complex containing isoform 2 is not able to cleave pre-tRNAs properly, although it retains endonucleolytic activity.
Gene: TSEN2
- Molekulargewicht
- 54 kDa
- Gen-ID
- 80746
- UniProt
- Q8NCE0
- Pathways
- Nuclear Receptor Transcription Pathway, Regulation of Lipid Metabolism by PPARalpha
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