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BAZ2A Antikörper (N-Term)

BAZ2A Reaktivität: Human ELISA, WB, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258712
  • Target Alle BAZ2A Antikörper anzeigen
    BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
    Bindungsspezifität
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    Human
    Wirt
    • 17
    • 1
    Kaninchen
    Klonalität
    • 18
    Polyklonal
    Konjugat
    • 8
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BAZ2A Antikörper ist unkonjugiert
    Applikation
    • 7
    • 7
    • 3
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    BAZ2A Antibody detects endogenous levels of total BAZ2A.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human BAZ2A, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product BAZ2A Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
    Andere Bezeichnung
    BAZ2A (BAZ2A Produkte)
    Synonyme
    zgc:101601 antikoerper, tip5 antikoerper, bax2a antikoerper, walp3 antikoerper, TIP5 antikoerper, WALp3 antikoerper, AA415431 antikoerper, C030005G16Rik antikoerper, C78388 antikoerper, Tip5 antikoerper, Walp3 antikoerper, mKIAA0314 antikoerper, bromodomain adjacent to zinc finger domain, 2A antikoerper, bromodomain adjacent to zinc finger domain 2A antikoerper, bromodomain adjacent to zinc finger domain 2A L homeolog antikoerper, Baz2a antikoerper, baz2a antikoerper, BAZ2A antikoerper, baz2a.L antikoerper
    Hintergrund

    Description: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).

    Gene: BAZ2A

    Molekulargewicht
    210 kDa
    Gen-ID
    11176
    UniProt
    Q9UIF9
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