BAZ2A Antikörper (N-Term)
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- Target Alle BAZ2A Antikörper anzeigen
- BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
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Bindungsspezifität
- N-Term
- Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser BAZ2A Antikörper ist unkonjugiert
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Applikation
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- BAZ2A Antibody detects endogenous levels of total BAZ2A.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human BAZ2A, corresponding to a region within N-terminal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product BAZ2A Primärantikörper
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- Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
- Andere Bezeichnung
- BAZ2A (BAZ2A Produkte)
- Synonyme
- zgc:101601 antikoerper, tip5 antikoerper, bax2a antikoerper, walp3 antikoerper, TIP5 antikoerper, WALp3 antikoerper, AA415431 antikoerper, C030005G16Rik antikoerper, C78388 antikoerper, Tip5 antikoerper, Walp3 antikoerper, mKIAA0314 antikoerper, bromodomain adjacent to zinc finger domain, 2A antikoerper, bromodomain adjacent to zinc finger domain 2A antikoerper, bromodomain adjacent to zinc finger domain 2A L homeolog antikoerper, Baz2a antikoerper, baz2a antikoerper, BAZ2A antikoerper, baz2a.L antikoerper
- Hintergrund
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Description: Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity).
Gene: BAZ2A
- Molekulargewicht
- 210 kDa
- Gen-ID
- 11176
- UniProt
- Q9UIF9
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