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EIF2AK1 Antikörper (C-Term)

EIF2AK1 Reaktivität: Human, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258766
  • Target Alle EIF2AK1 Antikörper anzeigen
    EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
    Bindungsspezifität
    • 7
    • 7
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 53
    • 26
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus
    Wirt
    • 53
    Kaninchen
    Klonalität
    • 53
    Polyklonal
    Konjugat
    • 25
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser EIF2AK1 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 26
    • 23
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    EIF2AK1 Antibody detects endogenous levels of total EIF2AK1.
    Homologie
    Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human EIF2AK1, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
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    Discover our top product EIF2AK1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
    Andere Bezeichnung
    EIF2AK1 (EIF2AK1 Produkte)
    Synonyme
    HCR antikoerper, Hri antikoerper, HRI antikoerper, wu:fj97h09 antikoerper, zgc:153232 antikoerper, eukaryotic translation initiation factor 2 alpha kinase 1 antikoerper, eukaryotic translation initiation factor 2-alpha kinase 1 antikoerper, eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog antikoerper, EIF2AK1 antikoerper, eif2ak1 antikoerper, Eif2ak1 antikoerper, eif2ak1.L antikoerper
    Hintergrund

    Description: Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity).

    Gene: EIF2AK1

    Molekulargewicht
    71 kDa
    Gen-ID
    27102
    UniProt
    Q9BQI3
    Pathways
    Hepatitis C
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