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GNA12 Antikörper (C-Term)

GNA12 Reaktivität: Human, Ratte, Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258823
  • Target Alle GNA12 Antikörper anzeigen
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Bindungsspezifität
    • 15
    • 8
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 44
    • 14
    • 14
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Human, Ratte, Maus
    Wirt
    • 44
    • 1
    Kaninchen
    Klonalität
    • 45
    Polyklonal
    Konjugat
    • 16
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GNA12 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 16
    • 13
    • 13
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    GNA12 Antibody detects endogenous levels of total GNA12.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human GNA12, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product GNA12 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Andere Bezeichnung
    GNA12 (GNA12 Produkte)
    Synonyme
    NNX3 antikoerper, RMP antikoerper, gep antikoerper, gna12 antikoerper, gna12l antikoerper, AI414047 antikoerper, AI504261 antikoerper, Galpha12 antikoerper, G protein subunit alpha 12 antikoerper, guanine nucleotide binding protein (G protein) alpha 12a antikoerper, guanine nucleotide binding protein, alpha 12 antikoerper, GNA12 antikoerper, Gna12 antikoerper, gna12a antikoerper
    Hintergrund

    Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

    Gene: GNA12

    Molekulargewicht
    44 kDa.
    Gen-ID
    2768
    UniProt
    Q03113
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