IREM1 Antikörper (Internal Region)
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- Target Alle IREM1 Antikörper anzeigen
- IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IREM1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- Spezifität
- CLM-1 Antibody detects endogenous levels of total CLM-1.
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human CLM-1, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product IREM1 Primärantikörper
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- Applikationshinweise
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
- Andere Bezeichnung
- CD300LF (IREM1 Produkte)
- Synonyme
- CLIM1 antikoerper, CLM-1 antikoerper, CLM1 antikoerper, Digr2 antikoerper, F730004D16Rik antikoerper, IREM1 antikoerper, IgSF13 antikoerper, LMIR3 antikoerper, Pigr3 antikoerper, CD300f antikoerper, RGD1309733 antikoerper, IREM-1 antikoerper, NKIR antikoerper, CD300 molecule like family member F antikoerper, Cd300 molecule-like family member F antikoerper, CD300 molecule like family member f antikoerper, Cd300lf antikoerper, CD300LF antikoerper
- Hintergrund
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Description: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition, recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).
Gene: CD300LF
- Molekulargewicht
- 30 kDa
- Gen-ID
- 146722
- UniProt
- Q8TDQ1
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