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IREM1 Antikörper (Internal Region)

IREM1 Reaktivität: Human WB, ELISA, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6258909
  • Target Alle IREM1 Antikörper anzeigen
    IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
    Bindungsspezifität
    • 8
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 37
    • 3
    • 1
    Human
    Wirt
    • 37
    • 2
    Kaninchen
    Klonalität
    • 37
    • 2
    Polyklonal
    Konjugat
    • 18
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IREM1 Antikörper ist unkonjugiert
    Applikation
    • 26
    • 25
    • 16
    • 16
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    CLM-1 Antibody detects endogenous levels of total CLM-1.
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human CLM-1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product IREM1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
    Andere Bezeichnung
    CD300LF (IREM1 Produkte)
    Synonyme
    CLIM1 antikoerper, CLM-1 antikoerper, CLM1 antikoerper, Digr2 antikoerper, F730004D16Rik antikoerper, IREM1 antikoerper, IgSF13 antikoerper, LMIR3 antikoerper, Pigr3 antikoerper, CD300f antikoerper, RGD1309733 antikoerper, IREM-1 antikoerper, NKIR antikoerper, CD300 molecule like family member F antikoerper, Cd300 molecule-like family member F antikoerper, CD300 molecule like family member f antikoerper, Cd300lf antikoerper, CD300LF antikoerper
    Hintergrund

    Description: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition, recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).

    Gene: CD300LF

    Molekulargewicht
    30 kDa
    Gen-ID
    146722
    UniProt
    Q8TDQ1
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