PARP2 Antikörper (Internal Region)

Produktnummer ABIN6259061

Produktdetails anti-PARP2 Antikörper

Target: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PARP2 Antibody detects endogenous levels of total PARP2.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PARP2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PARP2

Target: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Andere Bezeichnung: PARP2 (PARP2 Produkte)

Synonyme: ADPRT2 antikoerper, ADPRTL2 antikoerper, ADPRTL3 antikoerper, ARTD2 antikoerper, PARP-2 antikoerper, pADPRT-2 antikoerper, Adprt2 antikoerper, Adprtl2 antikoerper, Aspartl2 antikoerper, C78626 antikoerper, cb996 antikoerper, adprtl2 antikoerper, ADPRT-2 antikoerper, APP antikoerper, ATPARP1 antikoerper, PARP1 antikoerper, POLY(ADP-RIBOSE) POLYMERASE antikoerper, POLY(ADP-RIBOSE) POLYMERASE 1 antikoerper, PP antikoerper, T14P8.19 antikoerper, T14P8_19 antikoerper, poly(ADP-ribose) polymerase antikoerper, poly(ADP-ribose) polymerase 2 antikoerper, poly(ADP-ribose) polymerase 2 antikoerper, poly (ADP-ribose) polymerase family, member 2 antikoerper, poly (ADP-ribose) polymerase 2 antikoerper, poly(ADP-ribose) polymerase 2 S homeolog antikoerper, poly(ADP-ribose) polymerase antikoerper, PARP2 antikoerper, Parp2 antikoerper, parp2 antikoerper, parp2.S antikoerper

Hintergrund:

Description: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity (PubMed:28190768).

Gene: PARP2

Molekulargewicht: 75 kDa

Gen-ID: 10038

UniProt: Q9UGN5

Pathways: DNA Reparatur