NOC2L Antikörper (C-Term)

Produktnummer ABIN6259130

Produktdetails anti-NOC2L Antikörper

Target: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOC2L Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: NOC2L Antibody detects endogenous levels of total NOC2L.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human NOC2L, corresponding to a region within C-terminal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu NOC2L

Target: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Andere Bezeichnung: NOC2L (NOC2L Produkte)

Synonyme: NET15 antikoerper, NET7 antikoerper, NIR antikoerper, AA410003 antikoerper, AF155546 antikoerper, RGD1309387 antikoerper, NOC2 like nucleolar associated transcriptional repressor antikoerper, NOC2-like nucleolar associated transcriptional repressor antikoerper, NOC2L antikoerper, Noc2l antikoerper

Hintergrund:

Description: Acts as an inhibitor of histone acetyltransferase activity, prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter.

Gene: NOC2L

Molekulargewicht: 85 kDa

Gen-ID: 26155

UniProt: Q9Y3T9

Pathways: Negative Regulation of intrinsic apoptotic Signaling