nectin-3 Antikörper (Internal Region)

Produktnummer ABIN6259135

Produktdetails anti-nectin-3 Antikörper

Target: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser nectin-3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: PVRL3 Antibody detects endogenous levels of total PVRL3.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PVRL3, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu nectin-3

Target: nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))

Andere Bezeichnung: NECTIN3 (NECTIN3 Produkte)

Synonyme: PVRL3 antikoerper, CD113 antikoerper, CDW113 antikoerper, NECTIN-3 antikoerper, PPR3 antikoerper, PRR3 antikoerper, PVRR3 antikoerper, 2610301B19Rik antikoerper, 3000002N23Rik antikoerper, 4921513D19Rik antikoerper, AA407785 antikoerper, AU016832 antikoerper, AW538082 antikoerper, nectin cell adhesion molecule 3 antikoerper, poliovirus receptor-related 3 antikoerper, Nectin3 antikoerper, NECTIN3 antikoerper, PVRL3 antikoerper, nectin3 antikoerper

Hintergrund:

Description: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

Gene: NECTIN3

Molekulargewicht: 61 kDa

Gen-ID: 25945

UniProt: Q9NQS3

Pathways: Cell-Cell Junction Organization