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PPP1R16B Antikörper (Internal Region)

PPP1R16B Reaktivität: Human, Maus ELISA, WB, ICC, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259165
  • Target Alle PPP1R16B Antikörper anzeigen
    PPP1R16B (Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B))
    Bindungsspezifität
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 35
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 33
    • 2
    Kaninchen
    Klonalität
    • 35
    Polyklonal
    Konjugat
    • 14
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PPP1R16B Antikörper ist unkonjugiert
    Applikation
    ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    PPP1R16B Antibody detects endogenous levels of total PPP1R16B.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human PPP1R16B, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product PPP1R16B Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    PPP1R16B (Protein Phosphatase 1, Regulatory Subunit 16B (PPP1R16B))
    Andere Bezeichnung
    PPP1R16B (PPP1R16B Produkte)
    Synonyme
    ANKRD4 antikoerper, C130078N17Rik antikoerper, TIMAP antikoerper, Wdt4 antikoerper, protein phosphatase 1, regulatory (inhibitor) subunit 16B antikoerper, protein phosphatase 1 regulatory subunit 16B antikoerper, Ppp1r16b antikoerper, PPP1R16B antikoerper
    Hintergrund

    Description: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934).

    Gene: PPP1R16B

    Molekulargewicht
    64 kDa
    Gen-ID
    26051
    UniProt
    Q96T49
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