RAD51 Homolog B Antikörper
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- Target Alle RAD51 Homolog B (Rad51B) Antikörper anzeigen
- RAD51 Homolog B (Rad51B)
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Reaktivität
- Human, Maus, Affe
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser RAD51 Homolog B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Spezifität
- RAD51L1 Antibody detects endogenous levels of total RAD51L1
- Kreuzreaktivität
- Human, Affe, Maus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide
- Isotyp
- IgG
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- Applikationshinweise
- WB 1:500~1:1000 IHC: 1:50~1:200, IF/ICC 1:100-1:500
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C.Stable for 12 months from date of receipt
- Haltbarkeit
- 12 months
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- Target
- RAD51 Homolog B (Rad51B)
- Andere Bezeichnung
- RAD51L1 (Rad51B Produkte)
- Synonyme
- R51H2 antikoerper, RAD51L1 antikoerper, REC2 antikoerper, AI553500 antikoerper, Rad51l1 antikoerper, mREC2 antikoerper, ATRAD51B antikoerper, T17D12.12 antikoerper, T17D12_12 antikoerper, RGD1560681 antikoerper, rad51l1 antikoerper, wu:fd07f04 antikoerper, zgc:56581 antikoerper, RAD51 paralog B antikoerper, DNA repair (Rad51) family protein antikoerper, Rad51 DNA recombinase 2 antikoerper, RAD51B antikoerper, Rad51b antikoerper, rad51b antikoerper
- Hintergrund
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Description: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.
Gene: RAD51B
- Molekulargewicht
- 45 kDa
- Gen-ID
- 5890
- UniProt
- O15315
- Pathways
- DNA Reparatur
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