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RAD51 Homolog B Antikörper

Rad51B Reaktivität: Human, Maus, Affe WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259179
  • Target Alle RAD51 Homolog B (Rad51B) Antikörper anzeigen
    RAD51 Homolog B (Rad51B)
    Reaktivität
    • 14
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Affe
    Wirt
    • 11
    • 2
    • 1
    Kaninchen
    Klonalität
    • 13
    • 1
    Polyklonal
    Konjugat
    • 14
    Dieser RAD51 Homolog B Antikörper ist unkonjugiert
    Applikation
    • 13
    • 6
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    RAD51L1 Antibody detects endogenous levels of total RAD51L1
    Kreuzreaktivität
    Human, Affe, Maus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500~1:1000 IHC: 1:50~1:200, IF/ICC 1:100-1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C.Stable for 12 months from date of receipt
    Haltbarkeit
    12 months
  • Target
    RAD51 Homolog B (Rad51B)
    Andere Bezeichnung
    RAD51L1 (Rad51B Produkte)
    Synonyme
    R51H2 antikoerper, RAD51L1 antikoerper, REC2 antikoerper, AI553500 antikoerper, Rad51l1 antikoerper, mREC2 antikoerper, ATRAD51B antikoerper, T17D12.12 antikoerper, T17D12_12 antikoerper, RGD1560681 antikoerper, rad51l1 antikoerper, wu:fd07f04 antikoerper, zgc:56581 antikoerper, RAD51 paralog B antikoerper, DNA repair (Rad51) family protein antikoerper, Rad51 DNA recombinase 2 antikoerper, RAD51B antikoerper, Rad51b antikoerper, rad51b antikoerper
    Hintergrund

    Description: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway.

    Gene: RAD51B

    Molekulargewicht
    45 kDa
    Gen-ID
    5890
    UniProt
    O15315
    Pathways
    DNA Reparatur
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