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SRPK1 Antikörper (C-Term)

SRPK1 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259197
  • Target Alle SRPK1 Antikörper anzeigen
    SRPK1 (SRSF Protein Kinase 1 (SRPK1))
    Bindungsspezifität
    • 15
    • 9
    • 8
    • 7
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 60
    • 20
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 54
    • 6
    Kaninchen
    Klonalität
    • 55
    • 5
    Polyklonal
    Konjugat
    • 29
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SRPK1 Antikörper ist unkonjugiert
    Applikation
    • 36
    • 24
    • 13
    • 13
    • 12
    • 10
    • 9
    • 7
    • 5
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Spezifität
    SRPK1 Antibody detects endogenous levels of total SRPK1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SRPK1, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SRPK1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    SRPK1 (SRSF Protein Kinase 1 (SRPK1))
    Andere Bezeichnung
    SRPK1 (SRPK1 Produkte)
    Synonyme
    SFRSK1 antikoerper, AU017960 antikoerper, BEST:CK01209 antikoerper, CG11489 antikoerper, CG9085 antikoerper, CK01209 antikoerper, Dmel\\CG11489 antikoerper, SRPK antikoerper, SRPK1 antikoerper, Srpk79D antikoerper, atc antikoerper, srpk1 antikoerper, zgc:63789 antikoerper, wu:fc06h03 antikoerper, zgc:158800 antikoerper, sfrsk1 antikoerper, SRSF protein kinase 1 antikoerper, serine/arginine-rich protein specific kinase 1 antikoerper, Serine-arginine protein kinase at 79D antikoerper, SRSF protein kinase 1a antikoerper, SRSF protein kinase 1b antikoerper, SRSF protein kinase 1 S homeolog antikoerper, SRPK1 antikoerper, Srpk1 antikoerper, Srpk79D antikoerper, srpk1a antikoerper, srpk1b antikoerper, srpk1.S antikoerper
    Hintergrund

    Description: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activities, such as chromatin reorganization in somatic and sperm cells and cell cycle progression. Isoform 2 phosphorylates SFRS2, ZRSR2, LBR and PRM1. Isoform 2 phosphorylates SRSF1 using a directional (C-terminal to N-terminal) and a dual-track mechanism incorporating both processive phosphorylation (in which the kinase stays attached to the substrate after each round of phosphorylation) and distributive phosphorylation steps (in which the kinase and substrate dissociate after each phosphorylation event). The RS domain of SRSF1 binds first to a docking groove in the large lobe of the kinase domain of SRPK1. This induces certain structural changes in SRPK1 and/or RRM2 domain of SRSF1, allowing RRM2 to bind the kinase and initiate phosphorylation. The cycles continue for several phosphorylation steps in a processive manner (steps 1-8) until the last few phosphorylation steps (approximately steps 9-12). During that time, a mechanical stress induces the unfolding of the beta-4 motif in RRM2, which then docks at the docking groove of SRPK1. This also signals RRM2 to begin to dissociate, which facilitates SRSF1 dissociation after phosphorylation is completed. Isoform 2 can mediate hepatitis B virus (HBV) core protein phosphorylation. It plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles. Isoform 1 and isoform 2 can induce splicing of exon 10 in MAPT/TAU. The ratio of isoform 1/isoform 2 plays a decisive role in determining cell fate in K-562 leukaemic cell line: isoform 2 favors proliferation where as isoform 1 favors differentiation.

    Gene: SRPK1

    Molekulargewicht
    95 kDa
    Gen-ID
    6732
    UniProt
    Q96SB4
    Pathways
    Toll-Like Receptors Cascades
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