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FIL1h Antikörper (C-Term)

FIL1h Reaktivität: Human, Maus WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259273
  • Target Alle FIL1h Produkte
    FIL1h (Interleukin 1 eta (FIL1h))
    Bindungsspezifität
    • 8
    • 7
    • 4
    • 1
    • 1
    C-Term
    Reaktivität
    Human, Maus
    Wirt
    • 24
    • 6
    Kaninchen
    Klonalität
    • 26
    • 4
    Polyklonal
    Konjugat
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FIL1h Antikörper ist unkonjugiert
    Applikation
    • 23
    • 18
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    IL1F8 Antibody detects endogenous levels of total IL1F8.
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human IL1F8, corresponding to a region within C-terminal amino acids.
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Haltbarkeit
    12 months
  • Target
    FIL1h (Interleukin 1 eta (FIL1h))
    Andere Bezeichnung
    IL36B (FIL1h Produkte)
    Synonyme
    2310043N20Rik antikoerper, Il36b antikoerper, FIL1 antikoerper, FIL1-(ETA) antikoerper, FIL1H antikoerper, FILI-(ETA) antikoerper, IL-1F8 antikoerper, IL-1H2 antikoerper, IL1-ETA antikoerper, IL1F8 antikoerper, IL1H2 antikoerper, Il1f8 antikoerper, interleukin 1 family, member 8 antikoerper, interleukin 36 beta antikoerper, interleukin 36, beta antikoerper, Il1f8 antikoerper, IL36B antikoerper, Il36b antikoerper
    Hintergrund

    Description: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response, similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6.

    Gene: IL36B

    Molekulargewicht
    17 kDa?
    Gen-ID
    27177
    UniProt
    Q9NZH7
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