PLK2 Antikörper (Internal Region)

Produktnummer ABIN6259281

Produktdetails anti-PLK2 Antikörper

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PLK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Spezifität: PLK2 Antibody detects endogenous levels of total PLK2.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human PLK2, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu PLK2

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Andere Bezeichnung: PLK2 (PLK2 Produkte)

Synonyme: SNK antikoerper, hPlk2 antikoerper, hSNK antikoerper, Snk antikoerper, PLK2 antikoerper, Plx2 antikoerper, MGC53990 antikoerper, plk2 antikoerper, zgc:165644 antikoerper, polo like kinase 2 antikoerper, polo-like kinase 2 antikoerper, polo-like kinase 2 L homeolog antikoerper, polo-like kinase 2b (Drosophila) antikoerper, Serine/threonine-protein kinase plk-2 antikoerper, PLK2 antikoerper, Plk2 antikoerper, plk2.L antikoerper, plk2b antikoerper, plk2 antikoerper, plk-2 antikoerper

Hintergrund:

Description: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CENPJ and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress.

Gene: PLK2

Molekulargewicht: 78 kDa

Gen-ID: 10769

UniProt: Q9NYY3