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Shugoshin Antikörper (N-Term)

SGOL1 Reaktivität: Human, Maus, Ratte ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259304
  • Target Alle Shugoshin (SGOL1) Antikörper anzeigen
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Bindungsspezifität
    • 10
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reaktivität
    • 44
    • 4
    • 4
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 42
    • 3
    Kaninchen
    Klonalität
    • 43
    • 2
    Polyklonal
    Konjugat
    • 24
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Shugoshin Antikörper ist unkonjugiert
    Applikation
    • 30
    • 26
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB)
    Spezifität
    SGOL1 Antibody detects endogenous levels of total SGOL1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Xenopus
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human SGOL1, corresponding to a region within N-terminal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product SGOL1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))
    Andere Bezeichnung
    SGO1 (SGOL1 Produkte)
    Synonyme
    sgo1 antikoerper, NY-BR-85 antikoerper, SGO antikoerper, Sgo1 antikoerper, 3300001M08Rik antikoerper, C81037 antikoerper, shugoshin 1 antikoerper, shugoshin centromeric cohesion 1 antikoerper, shugoshin 1 L homeolog antikoerper, Sgo1 antikoerper, sgo1 antikoerper, sgo1.L antikoerper, SGO1 antikoerper
    Hintergrund

    Description: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.

    Gene: SGO1

    Molekulargewicht
    64 kDa
    Gen-ID
    151648
    UniProt
    Q5FBB7
    Pathways
    Maintenance of Protein Location
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