ALKBH5 Antikörper (Internal Region)

Produktnummer ABIN6259460

Produktdetails anti-ALKBH5 Antikörper

Target: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Spezifität: ALKBH5 Antibody detects endogenous levels of total ALKBH5.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ALKBH5, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Haltbarkeit: 12 months

Details zu ALKBH5

Target: ALKBH5 (AlkB, Alkylation Repair Homolog 5 (ALKBH5))

Andere Bezeichnung: ALKBH5 (ALKBH5 Produkte)

Synonyme: RGD1309496 antikoerper, ABH5 antikoerper, OFOXD antikoerper, OFOXD1 antikoerper, AW050020 antikoerper, AW215868 antikoerper, Abh5 antikoerper, E130207K11 antikoerper, Ofoxd antikoerper, alkB homolog 5, RNA demethylase antikoerper, alkB homolog 5, RNA demethylase L homeolog antikoerper, Alkbh5 antikoerper, alkbh5.L antikoerper, ALKBH5 antikoerper

Hintergrund:

Description: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N6-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N6-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).

Gene: ALKBH5

Molekulargewicht: ?44 kDa

Gen-ID: 54890

UniProt: Q6P6C2