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YOD1 Antikörper (Internal Region)

YOD1 Reaktivität: Human WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259576
  • Target Alle YOD1 Antikörper anzeigen
    YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
    Bindungsspezifität
    • 9
    • 8
    • 7
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 34
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 34
    Kaninchen
    Klonalität
    • 34
    Polyklonal
    Konjugat
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser YOD1 Antikörper ist unkonjugiert
    Applikation
    • 23
    • 18
    • 14
    • 13
    • 5
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    YOD1 Antibody detects endogenous levels of total YOD1.
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human YOD1, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product YOD1 Primärantikörper
  • Applikationshinweise
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    YOD1 (Ubiquitin Thioesterase OTU1 (YOD1))
    Andere Bezeichnung
    YOD1 (YOD1 Produkte)
    Synonyme
    DUBA8 antikoerper, OTUD2 antikoerper, PRO0907 antikoerper, hshin7 antikoerper, wu:fe01a10 antikoerper, zgc:112182 antikoerper, 9930028C20Rik antikoerper, Hshin7 antikoerper, YOD1 deubiquitinase antikoerper, YOD1 deubiquitinase L homeolog antikoerper, YOD1 antikoerper, Yod1 antikoerper, yod1.L antikoerper, yod1 antikoerper
    Hintergrund

    Description: Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. May recruit PLAA, UBXN6 and VCP to damaged lysosome membranes decorated with K48-linked ubiquitin chains and remove these chains allowing autophagosome formation (PubMed:27753622).

    Gene: YOD1

    Molekulargewicht
    35 kDa
    Gen-ID
    55432
    UniProt
    Q5VVQ6
    Pathways
    ER-Nucleus Signaling
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