UBQLN4 Antikörper (Internal Region)

Produktnummer ABIN6259665

Produktdetails anti-UBQLN4 Antikörper

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UBQLN4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Spezifität: A1Up Antibody detects endogenous levels of total A1Up.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human A1Up, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:1000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu UBQLN4

Target: UBQLN4 (Ubiquilin 4 (UBQLN4))

Andere Bezeichnung: UBQLN4 (UBQLN4 Produkte)

Synonyme: a1u antikoerper, cip75 antikoerper, ubin antikoerper, ubiquilin-4 antikoerper, A1U antikoerper, A1Up antikoerper, C1orf6 antikoerper, CIP75 antikoerper, UBIN antikoerper, A1u antikoerper, AI663987 antikoerper, RGD1308273 antikoerper, ubiquilin 4 L homeolog antikoerper, ubiquilin 4 antikoerper, ubqln4.L antikoerper, ubqln4 antikoerper, UBQLN4 antikoerper, Ubqln4 antikoerper

Hintergrund:

Description: Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:15280365). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205).

Gene: UBQLN4

Molekulargewicht: 54kDa

Gen-ID: 56893

UniProt: Q9NRR5