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Actin-Like 6B Antikörper (Internal Region)

ACTL6B Reaktivität: Human, Maus WB, ELISA, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6259751
  • Target Alle Actin-Like 6B (ACTL6B) Antikörper anzeigen
    Actin-Like 6B (ACTL6B)
    Bindungsspezifität
    • 8
    • 8
    • 6
    • 2
    • 1
    • 1
    • 1
    Internal Region
    Reaktivität
    • 31
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 31
    • 1
    Kaninchen
    Klonalität
    • 31
    • 1
    Polyklonal
    Konjugat
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Actin-Like 6B Antikörper ist unkonjugiert
    Applikation
    • 25
    • 19
    • 15
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    ACTL6B Antibody detects endogenous levels of total ACTL6B.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Aufreinigung
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogen
    A synthesized peptide derived from human ACTL6B, corresponding to a region within the internal amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product ACTL6B Primärantikörper
  • Applikationshinweise
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20 °C. Stable for 12 months from date of receipt.
    Haltbarkeit
    12 months
  • Target
    Actin-Like 6B (ACTL6B)
    Andere Bezeichnung
    ACTL6B (ACTL6B Produkte)
    Synonyme
    MGC110167 antikoerper, zgc:110167 antikoerper, ACTL6 antikoerper, BAF53B antikoerper, Actl6 antikoerper, ArpNa antikoerper, Baf53b antikoerper, actin-like 6B antikoerper, actin like 6B antikoerper, actl6b antikoerper, ACTL6B antikoerper, Actl6b antikoerper
    Hintergrund

    Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth (By similarity).

    Gene: ACTL6B

    Molekulargewicht
    47 kDa
    Gen-ID
    51412
    UniProt
    O94805
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