ACVR2B Antikörper (Internal Region)
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- Target Alle ACVR2B Antikörper anzeigen
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ACVR2B Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Spezifität
- ACVR2B Antibody detects endogenous levels of total ACVR2B.
- Homologie
- Pig,Bovine,Horse,Dog,Chicken,Xenopus
- Aufreinigung
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human ACVR2B, corresponding to a region within the internal amino acids.
- Isotyp
- IgG
- Top Product
- Discover our top product ACVR2B Primärantikörper
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- Applikationshinweise
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20 °C. Stable for 12 months from date of receipt.
- Haltbarkeit
- 12 months
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- Target
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Andere Bezeichnung
- ACVR2B (ACVR2B Produkte)
- Synonyme
- ACVR2B antikoerper, XAR1 antikoerper, actr-iib antikoerper, actriib antikoerper, ACTRIIB antikoerper, ActR-IIB antikoerper, HTX4 antikoerper, ActRIIB antikoerper, actr2b antikoerper, actrIIb antikoerper, wu:fj97d11 antikoerper, activin A receptor type 2B antikoerper, activin A receptor type 2B L homeolog antikoerper, activin A receptor type 2Ba antikoerper, activin receptor IIB antikoerper, ACVR2B antikoerper, acvr2b antikoerper, acvr2b.L antikoerper, Acvr2b antikoerper, acvr2ba antikoerper
- Hintergrund
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Description: Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.
Gene: ACVR2B
- Molekulargewicht
- 58 kDa
- Gen-ID
- 93
- UniProt
- Q13705
- Pathways
- Hormone Transport, Cancer Immune Checkpoints
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